Endocrine Abstracts

Introduction: Elevated intraocular (vitreous) leptin is implicated in proliferative diabetic retinopathy. The source of vitreous leptin is uncertain and it could be derived from systemic leptin. However we showed that leptin (ob) mRNA is present in rat retina, suggesting that retinal tissue could also be a source of intraocular leptin. The present investigation quantified ob mRNA in human retinal tissue obtained from diabetic and control cadavers. In a parall...